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Late recurrence while public opinion often equates surviving 5 years with breast cancer to a cure breast cancers may recur at a later time in fact estrogen receptor positive breast cancers are more likely to recur after 5 years than in the first 5 years following diagnosisa 2018 study looking at recurrence after 5 years of hormonal therapy tamoxifen or an aromatase inhibitor found that . Breast cancer can recur at any time but most recurrences occur in the first three to five years after initial treatment breast cancer can come back as a local recurrence in the treated breast or near the mastectomy scar or as a distant recurrence somewhere else in the bodythe most common sites of recurrence include the lymph nodes the bones liver or lungs. A study found that survival rates are much better when any second breast cancer is detected early researchers looked at the medical records of 1044 women in florence italy who were diagnosed and successfully treated for early stage breast cancer. Regional the cancer has spread outside the breast to nearby structures or lymph nodes distant the cancer has spread to distant parts of the body such as the lungs liver or bones 5 year relative survival rates for breast cancer based on women diagnosed with breast cancer between 2010 and 2016